HESI A2 Anatomy and Physiology Practice Test: a 120-question practice bank for the real Healthcare & Pharmacy Certification standard, 4 full papers of 30 questions each with no repeats, every question written to the exam sponsor's published content outline.
Where these questions come from
Every question in this bank cites a real source -- primarily HESI A2 Anatomy and Physiology | Nervous system (12%) and HESI A2 Anatomy and Physiology | Cardiovascular system (12%) of this exam's citations.
Independent study tool for the HESI A2 Anatomy and Physiology section. Not affiliated with, sponsored by, or endorsed by Elsevier Inc. HESI and Evolve are trademarks of Elsevier Inc. Elsevier does not publish section question counts, time limits, passing scores, fees or retake rules for the HESI A2; the 30-question length and 25-minute timer used here are the figures published by nursing schools that run the exam, and your program may configure the section differently. Schools report that 30 questions are shown and 25 are scored, with 5 unscored pilot items you cannot identify, and that you cannot skip a question or go back. This practice test scores every question and lets you review at the end. There is no Elsevier pass mark: your program sets its own cutoff (75 percent per section is a common one), its own fee and its own retake policy, and it chooses which sections you sit. Check your school's page.
Not sure where you stand? Take the free diagnostic — 10 real questions across the exam's domains, no sign-up required, with a domain-by-domain breakdown at the end.
Which organelle is the main site of ATP production in a human cell?
A. Golgi apparatus
B. Mitochondrion
C. Lysosome
D. Ribosome
Show answer and reasoning
Correct answer: B. Mitochondrion
Correct. Mitochondria carry out aerobic cellular respiration and generate most of the cell's ATP.
A: The Golgi apparatus modifies, sorts and packages proteins for transport.
C: Lysosomes contain digestive enzymes that break down waste and worn-out organelles.
D: Ribosomes assemble proteins from amino acids.
Source: HESI A2 Anatomy and Physiology | Cells and histology
Which type of tissue covers body surfaces and lines hollow organs and body cavities?
A. Connective tissue
B. Muscle tissue
C. Nervous tissue
D. Epithelial tissue
Show answer and reasoning
Correct answer: D. Epithelial tissue
Correct. Epithelial tissue forms coverings and linings, including the skin surface and the lining of the digestive tract.
A: Connective tissue supports and binds other tissues; examples are bone, cartilage, blood and adipose tissue.
B: Muscle tissue contracts to produce movement.
C: Nervous tissue transmits electrical signals.
Source: HESI A2 Anatomy and Physiology | Cells and histology
Which mineral makes up most of the hard matrix of bone and is stored there for release into the blood?
A. Iron
B. Calcium
C. Potassium
D. Sodium
Show answer and reasoning
Correct answer: B. Calcium
Correct. Calcium phosphate crystals harden bone, and bone serves as the body's main calcium reservoir.
A: Iron is stored mainly in the liver and in hemoglobin, not in bone matrix.
C: Potassium is the main intracellular ion and is not a bone mineral.
D: Sodium is the main extracellular fluid ion; it is not a structural bone mineral.
Source: HESI A2 Anatomy and Physiology | Skeletal system
A fibrous connective tissue band that connects one bone to another bone at a joint is called which of the following?
A. Fascia
B. Ligament
C. Tendon
D. Cartilage
Show answer and reasoning
Correct answer: B. Ligament
Correct. Ligaments join bone to bone and stabilize joints.
A: Fascia is a sheet of connective tissue that surrounds muscles and organs.
C: Tendons connect muscle to bone.
D: Cartilage cushions joint surfaces and forms structures such as the nose and ear, but it is not a band linking bones.
Source: HESI A2 Anatomy and Physiology | Skeletal system
Which bone of the forearm is on the thumb side when the palm faces forward?
A. Humerus
B. Scaphoid
C. Radius
D. Ulna
Show answer and reasoning
Correct answer: C. Radius
Correct. The radius is the lateral forearm bone, on the same side as the thumb.
A: The humerus is the upper arm bone, not a forearm bone.
B: The scaphoid is a wrist (carpal) bone, not a forearm bone.
D: The ulna is the medial forearm bone, on the little-finger side.
Source: HESI A2 Anatomy and Physiology | Skeletal system
Frequently asked questions
How many questions are on the CertQuestUSA HESI A2 Anatomy and Physiology Practice Test practice test?
120 questions total, split into 4 full papers of 30 each with no repeats across papers.
What topics does the HESI A2 Anatomy and Physiology Practice Test test cover?
13 domains, with the heaviest weight on Cardiovascular System (10%), Nervous System (10%), and Terminology And Orientation (10%).
Where do CertQuestUSA's HESI A2 Anatomy and Physiology Practice Test questions come from?
Primarily HESI A2 Anatomy and Physiology | Nervous system (12%) and HESI A2 Anatomy and Physiology | Cardiovascular system (12%) of this bank's citations -- computed directly from this exam's own question sources, not a generic description.
Is there a free diagnostic for HESI A2 Anatomy and Physiology Practice Test?
Yes -- 10 real questions across the exam's domains, no sign-up required, with a domain-by-domain breakdown at the end.
